Tualang Honey prevents neuronal damage in medial prefrontal cortex (mPFC) through enhancement of cholinergic system in male rats following exposure to normobaric hypoxia

Background: Medial prefrontal cortex (mPFC) is considered to be involved in human cognition mPFCin terms of learning and memory. Hypoxia one the crucial factors causing secondary damage incerebral hemorrhage traumatic brain injury. However, underlying mechanisms possibletherapeutic approach prevent neuronal has not been attempted yet. Therefore, present studyaimed investigate role Tualang honey on medial cortical morphology andcholinergic markers such as acetylcholine (ACh) acetylcholinesterase (AChE) following exposure normobaric hypoxia rats.
 Material methods: Adult male Sprague-Dawley rats were dividedinto four groups: (i) sucrose treated non-hypoxia, (ii) hypoxia, (iii) honeytreated non-hypoxia (iv)Tualang hypoxia. Rats received (1 mL 7.9%) andTualang (0.2 g/kg), respectively, for 2 weeks prior exposure. Morphological study wasperformed by using Nissl staining cholinergic estimated ELISA technique.
 Resultsand discussion: Sucrose group showed significantly lower mean ACh higher meanAChE concentrations (P<0.05) compared groups. Interestingly,mean concentration was increased AChE significantlydecreased hypoxic rats. Morphologicaldata that caused mPFC whereasTualang damage.
 Conclusion: honeyprotects hypoxia-induced through improvement markersin exposed hypoxia.
 Bangladesh Journal Medical Science Vol.20(1) 2021 p.122-129